Cannabidiol (CBD): Cannabidiol has demonstrated preliminary efficacy for a range of physical and mental health care problems. Reviewed studies suggested that cannabinoids could improve sleep quality, decrease sleep disturbances, and decrease sleep onset latency.
Curcumin: Curcuma longa has shown potent anti-inflammatory effects, scavenges both nitrous oxide and superoxide, inhibits COX -2 Cyclooxygenase, and upregulates peroxisome proliferator-activated receptor-y (PPAR-y). This leads to the suppression of proinflammatory cytokine, TNF-a expression and release.
Boswellia: Boswellia serrara contains boswellic acids, which were found to selectively inhibit the synthesis of the pro-inflammatory enzyme 5-lipoxygenase (5-LO), as well as 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB-4), which cause bronchoconstriction, chemotaxis, and increased vascular permeability. These acids have also been show to trigger inhibition of human leukocyte elastase (HLE).
Devil’s Claw: Has been found to suppress oxidative/nitrosative stress and inflammatory responses including nitric oxide and reactive oxygen species production, phosphorylation of cytosolic phospholipases A2, and upregulation of antioxidative stress pathways in spinal cord injuries.
Bromelain: Ananas comosus has been shown to mitigate neuropathic pain by enhancing NfF-1 and NrF2 activities and subsequently increasing antioxidant effects. It has also been found to decrease post-surgical pain and swelling.
Ginger Extract: Contains 6-shogaol which has be show to reduce pain symptoms in painful diabetic neuropathy via its effect on decreasing TRPV1 and NMDAR2B expressions in the spinal cord.
Green Tea Extract: EGCG has been shown to significantly suppress interleukin-1 beta (IL-1B)-induced elevation of mRNA expression of pain mediators, proinflammatory cytokines, and matrix metalloproteinases (MMPs) in vitro.
Resveratrol: This natural phenol has been found to have antinociceptive effects on visceral hyperalgesia through inhibition of spinal TRAF6/NF-kB mediated neuroinflammation.
Capsaicin: Induces desensitization of TRPV1 receptors and the depletion of pain signaling neuropeptides in nerve fibers, including Substance P, leading to analgesic effects.
Green Maeng Da: Myitragyna speciosa dampens nociceptive responses through occupation of the MGM-9 kappa-opioid receptor and demonstrated anti-inflammatory effects as alpha-2 agonists.
Corydalis Root: Exhibits neural mediated analgesic effects through pH mediated inhibition of acid-sensing ion channels in dorsal root ganglion cells.
Cat’s Claw: Known as the “life-giving vine of Peru”, is a thick woody vine indigenous to the Amazon rainforest. The mechanism of Cat’s Claw appears to be as an inhibitor of TNFα and an antioxidant. Some research shows that Cat’s Claw may help with those experiencing osteoarthritis and pain caused by inflammation.
Marshmallow Root: Because marshmallow root is mucilaginous (slimy), when taken internally it is classified as a demulcent, it’s an herb that forms a soothing film over the mucous membrane. Marshmallow root has one of the strongest antioxidant effects of many herbs that have been tested. Marshmallow root has been shown to be effective in reducing skin inflammation. Research shows it to be helpful in treating Crohn’s disease, ulcerative colitis and other inflammatory bowel diseases. It’s also soothing to stomach ulcers and potential treats simple indigestion.
Humulene: A terpene abundant in the hops plant, has been shown to help control inflammation and boost the body’s immune responses.
Caryophyllene: A terpene with a peppery flavor, is the only terpene known to act on the endocannabinoid system. By activating CB2 receptors it plays a key role in the reduction of pain sensation and inflammation